Altered Presence of Cancer Stem Cell ALDH1/2 in Oral Leukoplakias and Squamous Cell Carcinomas
نویسندگان
چکیده
Introduction: Cancer stem cells (CSCs) are responsible for initiating the process of carcinogenesis by enabling self-renewal and self-proliferation cancer cells. This study aimed to investigate presence epithelial with characteristics (ALDH+) in early stages oral precancerous lesions (Oral Leukoplakias) frequency these different squamous cell carcinomas (OSCCs). Materials & methods: The aim this was detection immunohistochemical pattern expression CSC protein-biomarker ALDH1&2 (sc-166362, Santa Cruz Co, Dallas, Texas, USA) paraffin-embedded samples 30 cases leukoplakia all degrees dysplasia 21 (OSCC) differentiation compared histologically normal epithelium. were retrieved from 2009-2019 archives Department Oral Medicine/Pathology, School Dentistry, Aristotle University Thessaloniki, Greece. evaluated through a three-tier scale (positive Ι: 6-35%, ΙΙ: 36-70%, ΙΙΙ: 71-100%). Statistical analysis performed SPSS Pearson Chi-square, significance level set at 0.05 (p=0.05). Results: staining observed mildly membrane stratum spinosum epithelium basale epithelium, characteristically interface point basal membrane. expressed significantly more OSCC than (p-value=0.0001) (p-value=0.0001). Mainly, severely moderately dysplastic non-dysplastic (p-value=0.001). Discussion: characteristic ALDH potentially malignant suggests CSCs their possible implication tumorigenesis, even stage leukoplakia.
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ژورنال
عنوان ژورنال: Cureus
سال: 2023
ISSN: ['2168-8184']
DOI: https://doi.org/10.7759/cureus.40836